Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites

J Am Chem Soc. 2002 Apr 10;124(14):3496-7. doi: 10.1021/ja0127279.

Abstract

A unique pentaketide dimer structure of a novel fungal metabolite with antiangiogenic activity, designated as epoxyquinol A (1), was determined on the basis of NMR spectral data as well as the X-ray crystallographic analysis. 1 inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 3 mug/mL).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / chemistry
  • Angiogenesis Inhibitors / isolation & purification*
  • Angiogenesis Inhibitors / pharmacology*
  • Epoxy Compounds / chemistry
  • Epoxy Compounds / isolation & purification*
  • Epoxy Compounds / pharmacology*
  • Fungi / chemistry*
  • Hydroquinones / chemistry
  • Hydroquinones / isolation & purification*
  • Hydroquinones / pharmacology*
  • Nuclear Magnetic Resonance, Biomolecular / methods
  • Soil Microbiology

Substances

  • Angiogenesis Inhibitors
  • Epoxy Compounds
  • Hydroquinones
  • epoxyquinol A