A conserved family of doublesex-related genes from fishes

J Exp Zool. 2002 Apr 15;294(1):63-7. doi: 10.1002/jez.10044.

Abstract

The sex-determining gene Mab-3 of C. elegans and the doublesex gene of Drosophila each contain a common DM domain and share a similar role. Human doublesex-related gene DMRT1 also encodes a conserved DM-related DNA-binding domain. We present here the amplification of a broad range of DM domain sequences from three fish species using degenerate PCR. Our results reveal unexpected complexity of the DM domain gene family in vertebrates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Conserved Sequence / genetics*
  • DNA-Binding Proteins*
  • Eels / genetics
  • Female
  • Fishes / genetics*
  • Humans
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sex Determination Processes
  • Transcription Factors / chemistry
  • Transcription Factors / genetics*
  • Zebrafish / genetics
  • Zebrafish Proteins*

Substances

  • DMRT1 protein
  • DMRT2 protein, human
  • DNA-Binding Proteins
  • Transcription Factors
  • Zebrafish Proteins
  • dmrt2a protein, zebrafish

Associated data

  • GENBANK/AF272954
  • GENBANK/AF272955
  • GENBANK/AF272956
  • GENBANK/AF272957
  • GENBANK/AF272958
  • GENBANK/AF272959
  • GENBANK/AF272960
  • GENBANK/AF272961
  • GENBANK/AF272962
  • GENBANK/AF272963
  • GENBANK/AF272964
  • GENBANK/AF272965
  • GENBANK/AF272966
  • GENBANK/AF272967
  • GENBANK/AF272968
  • GENBANK/AF272969
  • GENBANK/AF272970
  • GENBANK/AF272971
  • GENBANK/AF272972
  • GENBANK/AF378149