Concomitant tetrasomy 3q and trisomy 18 in CD5(-), CD13(+) chronic lymphocytic leukemia

Cancer Genet Cytogenet. 2002 Mar;133(2):160-3. doi: 10.1016/s0165-4608(01)00583-0.

Abstract

Chronic lymphocytic leukemia (CLL) associated with myeloid antigens on the surface of B neoplastic cells is a recently identified immunologic variant confined to patients with CD5 negative B-CLL. We describe the case of a 61-year-old female diagnosed with CD5(-), CD13(+) B-CLL with a tetrasomy 3q revealed by fluorescence in situ hybridization analysis, in addition to trisomy 18. To our knowledge, this is the first reported case of B-CLL with this kind of cytogenetic abnormality.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD13 Antigens / metabolism*
  • CD5 Antigens / metabolism*
  • Chromosomes, Human, Pair 18 / genetics*
  • Chromosomes, Human, Pair 3 / genetics*
  • Female
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism
  • Middle Aged
  • Trisomy*

Substances

  • CD5 Antigens
  • CD13 Antigens