Synthesis and antifungal activity of new N-(1-phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides

Farmaco. 2002 Mar;57(3):183-7. doi: 10.1016/s0014-827x(01)01190-9.

Abstract

N-(1-Phenyl-4-carbetoxypyrazol-5-yl)-, N-(indazol-3-yl)- and N-(indazol-5-yl)-2-iodobenzamides 6, with a Benodanil-like structure, were synthesized by refluxing in acetic acid the corresponding benzotriazinones 5 with potassium iodide for 1 h in order to study the role on the antifungal activity of the N-substitution with an aromatic heterocyclic system on benzamide moiety. Among the tested iododerivatives, compounds 6d,f,g,h possess interesting activities toward some phytopathogenic fungal strains.

Publication types

  • Comparative Study

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology*
  • Benzamides / chemical synthesis*
  • Benzamides / pharmacology*
  • Colony Count, Microbial
  • Fungi / drug effects
  • Fungi / growth & development
  • Indazoles / chemical synthesis*
  • Indazoles / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / pharmacology*
  • Spectrophotometry, Infrared

Substances

  • Antifungal Agents
  • Benzamides
  • Indazoles
  • Pyrazoles
  • pyrazole