A radiochemical heavy ion activation procedure was carried out for the simultaneous production of carrier-free 48V and 48,49Cr in 7Li ion irradiated Sc2O3 target, followed by the separation of the individual radio-elements in pure form through liquid-liquid extraction using liquid cation exchanger, di-(2-ehtylhexyl) phosphoric acid. Liquid anion exchanger, trioctylamine, was used to obtain extractants from aqueous acid solutions under different experimental conditions.