This study evaluated 2 end-to-side nerve repair techniques for ability to induce nerve sprouting and muscular recovery. Twenty-four rats underwent identical surgeries. The helicoid method of neurorrhaphy was used on the left (large epineurial window) side and the standard end-to-side (small epineurial window) repair on the right side of each rat to repair the peroneal nerve. The helicoid configuration markedly increases the area from which axons can sprout into the recipient nerve. At 11 months after surgery, axons were counted in donor and recipient nerves, and muscle moist weight of the extensor digitorum longus (EDL) and tetanic force were measured. Muscle volume, tetanic force, and moist weight of EDL muscles were significantly higher on the left side (helicoid) than on the right (end-to-side). Histologic analysis and nerve axon counting of the recipient peroneal nerve showed significantly more regenerative nerves on the left than on the right. There were no significant differences between sites above and below the repair site in the donor tibial nerve in regard to mean number of nerve fibers. Helicoid nerve repair can entice more nerve fiber sprouts from the intact donor nerve, improve muscular recovery, and maintain donor nerve health.