International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice

Ann N Y Acad Sci. 2002 Apr:958:1-2. doi: 10.1111/j.1749-6632.2002.tb02941.x.

Abstract

The aim of this workshop was to identify autoantibody assays that could provide useful markers of autoimmunity in the NOD mouse model for type 1 diabetes. It was demonstrated that insulin autoantibodies measured by sensitive radiobinding assay are a marker of autoimmunity in NOD mice and draw into question the true nature of GADA and IA-2A in this animal model.

Publication types

  • Congress

MeSH terms

  • Animals
  • Autoantibodies / immunology*
  • Autoantigens / immunology*
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Disease Models, Animal*
  • Glutamate Decarboxylase / immunology
  • Humans
  • Insulin / immunology
  • Mice
  • Mice, Inbred NOD

Substances

  • Autoantibodies
  • Autoantigens
  • Insulin
  • Glutamate Decarboxylase