Discovery and evaluation of N-(triazin-1,3,5-yl) phenylalanine derivatives as VLA-4 integrin antagonists

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1591-4. doi: 10.1016/s0960-894x(02)00237-8.

Abstract

SAR studies aimed at improving the rate of clearance of a series of VLA-4 integrin antagonists by the introduction of a 1,3,5-triazine as an amide isostere are described.

Publication types

  • Evaluation Study

MeSH terms

  • Integrin alpha4beta1 / antagonists & inhibitors*
  • Phenylalanine / analogs & derivatives
  • Phenylalanine / chemistry*
  • Phenylalanine / pharmacology*
  • Structure-Activity Relationship
  • Triazines / chemistry*
  • Triazines / pharmacology*

Substances

  • Integrin alpha4beta1
  • N-(triazin-1,3,5-yl) phenylalanine
  • Triazines
  • Phenylalanine