Oesophagogastroduodenitis (OGD) is a frequent situation in the newborn and run a benign course. Ninety cases of OGD were studied. Diagnosis was established by endoscopy. Presenting symptoms are dominated by gastrointestinal bleeding (70 percent of cases). Oesophagitis and/or gastritis were observed in all cases, associated with duodenitis in 34.5 percent of cases. Evolution was good with complete recovery of the symptoms and healing of mucosal lesions in 74.4 percent of controlled patients. Pathogenesis of neonatal OGD remains undetermined.