Nationwide survey of in vitro activities of itraconazole and voriconazole against clinical Aspergillus fumigatus isolates cultured between 1945 and 1998

J Clin Microbiol. 2002 Jul;40(7):2648-50. doi: 10.1128/JCM.40.7.2648-2650.2002.

Abstract

The isolates in a collection of 170 Aspergillus fumigatus isolates recovered from 114 patients and 21 different medical centers in The Netherlands over a period of 53 years were tested for the presence of resistance to itraconazole and voriconazole according to the guidelines of NCCLS document M38-P and by the E-test. Three isolates were highly resistant to itraconazole, and voriconazole MICs were low for all isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillosis / drug therapy
  • Aspergillosis / microbiology
  • Aspergillus fumigatus / drug effects*
  • Aspergillus fumigatus / isolation & purification
  • Drug Resistance, Fungal
  • Humans
  • In Vitro Techniques
  • Itraconazole / pharmacology*
  • Microbial Sensitivity Tests
  • Netherlands
  • Pyrimidines / pharmacology*
  • Time Factors
  • Triazoles / pharmacology*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • Voriconazole