Abstract
The fsr locus of Enterococcus faecalis confers virulence in animal models. A retrospective analysis of fsr prevalence in diverse E. faecalis clinical isolates demonstrated fsr in all endocarditis isolates versus 53% of stool isolates (P = 0.005). This supports a role for fsr-mediated virulence in the pathogenesis of enterococcal infections in humans.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Bacterial Proteins / genetics
-
Base Sequence
-
DNA, Bacterial / genetics
-
Endocarditis, Bacterial / microbiology
-
Enterococcus faecalis / genetics*
-
Enterococcus faecalis / pathogenicity*
-
Genes, Bacterial*
-
Gram-Positive Bacterial Infections / microbiology*
-
Humans
-
Retrospective Studies
-
Virulence / genetics
Substances
-
AgrCfs protein, Enterococcus faecalis
-
Bacterial Proteins
-
DNA, Bacterial
-
FsrA protein, Enterococcus faecalis
-
FsrB protein, Enterococcus