Ravuconazole Eisai/Bristol-Myers Squibb

Curr Opin Investig Drugs. 2002 Apr;3(4):555-61.

Abstract

Eisai and Bristol-Myers Squibb (BMS) are developing the triazole, ravuconazole, as a potential treatment for fungal infection [187888]. Eisai selected the compound for further development on the basis of its good safety profile and well-balanced antifungal activity [187888]. Ravuconazole has a broader antifungal spectrum than fluconazole and itraconazole, particularly against strains of Candida krusei and Cryptococcus neoformans [271854], [342757], [370312]. By June 1999, the compound was undergoing phase II trials [327113]. In November 2001, it was reported that BMS was seeking a co-development partner for the compound [430011]. In October 2001, analysts at ABN Amro predicted sales of US $50 million in 2003 [444020].

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Antifungal Agents / adverse effects
  • Antifungal Agents / metabolism
  • Antifungal Agents / pharmacology*
  • Clinical Trials as Topic
  • Humans
  • Mycoses / drug therapy
  • Structure-Activity Relationship
  • Thiazoles / adverse effects
  • Thiazoles / metabolism
  • Thiazoles / pharmacology*
  • Triazoles / adverse effects
  • Triazoles / metabolism
  • Triazoles / pharmacology*

Substances

  • Antifungal Agents
  • Thiazoles
  • Triazoles
  • ER 30346