Ectopic growth hormone-releasing hormone secretion by thymic carcinoid tumour

Clin Endocrinol (Oxf). 2002 Jul;57(1):131-4. doi: 10.1046/j.1365-2265.2002.01535.x.

Abstract

The case of a 33-year-old-woman with Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome and acromegaly due to ectopic growth hormone-releasing hormone (GHRH) secretion by a thymic carcinoid tumour is reported. Immunohistochemistry revealed positive immunoreactivity for GHRH, vasoactive intestinal polypeptide, somatostatin and alpha-subunit in the tumour cells. A previously undescribed new germ line mutation of the MEN1 protein gene was revealed.

Publication types

  • Case Reports

MeSH terms

  • Acromegaly / drug therapy
  • Acromegaly / etiology*
  • Adult
  • Antineoplastic Agents / therapeutic use
  • Carcinoid Tumor / chemistry
  • Carcinoid Tumor / drug therapy
  • Carcinoid Tumor / metabolism*
  • Fatal Outcome
  • Female
  • Germ-Line Mutation
  • Growth Hormone-Releasing Hormone / analogs & derivatives
  • Growth Hormone-Releasing Hormone / analysis
  • Growth Hormone-Releasing Hormone / metabolism*
  • Humans
  • Immunohistochemistry
  • Multiple Endocrine Neoplasia Type 1 / chemistry
  • Multiple Endocrine Neoplasia Type 1 / drug therapy
  • Multiple Endocrine Neoplasia Type 1 / genetics
  • Multiple Endocrine Neoplasia Type 1 / metabolism*
  • Neoplasm Proteins / analysis
  • Neoplasm Proteins / metabolism*
  • Peptides, Cyclic / therapeutic use
  • Somatostatin / analogs & derivatives
  • Somatostatin / analysis
  • Somatostatin / therapeutic use
  • Thymus Neoplasms / chemistry
  • Thymus Neoplasms / metabolism*
  • Vasoactive Intestinal Peptide / analysis

Substances

  • Antineoplastic Agents
  • Neoplasm Proteins
  • Peptides, Cyclic
  • lanreotide
  • Vasoactive Intestinal Peptide
  • Somatostatin
  • Growth Hormone-Releasing Hormone