T-wave patterns associated with the hereditary long QT syndrome

Card Electrophysiol Rev. 2002 Sep;6(3):311-5. doi: 10.1023/a:1016301730302.

Abstract

Mutations involving 6 different ion-channel genes have been identified in subjects with the hereditary Long QT Syndrome. These gene mutations result in structural and functional changes in ion-channel proteins with resultant alterations in potassium and sodium repolarization currents that affect the morphologic features of electrocardiographic repolarization. This review highlights the genotype-phenotype associations related to ventricular repolarization that have been reported in the LQTS literature, with particular focus on ECG T-wave patterns in LQT1, LQT2, and LQT3 genotypes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Electrocardiography / methods*
  • Genotype
  • Humans
  • Infant
  • Long QT Syndrome / genetics*
  • Long QT Syndrome / physiopathology*
  • Middle Aged
  • Mutation* / genetics
  • Mutation* / physiology
  • Phenotype
  • Potassium Channels / physiology
  • Sodium Channels / physiology

Substances

  • Potassium Channels
  • Sodium Channels