Myc-Is this the oncogene from Hell?

Laura Soucek; Gerard Evan

doi:10.1016/s1535-6108(02)00077-6

Myc-Is this the oncogene from Hell?

Cancer Cell. 2002 Jun;1(5):406-8. doi: 10.1016/s1535-6108(02)00077-6.

Authors

Laura Soucek¹, Gerard Evan

Affiliation

¹ Cancer Research Institute, University of California, San Francisco, Cancer Center, 2340 Sutter Street, 94143, USA.

PMID: 12124167
DOI: 10.1016/s1535-6108(02)00077-6

Abstract

A new paper implicates the Myc oncoprotein in the direct induction of DNA damage and consequent genome instability in cultured cells. However, it is less clear whether Myc induces the same genetic pandemonium in vivo.

Publication types

Review

MeSH terms

DNA Damage / physiology*
Fibroblasts / metabolism
Humans
Proto-Oncogene Proteins c-myc / physiology*
Reactive Oxygen Species / metabolism

Substances

Proto-Oncogene Proteins c-myc
Reactive Oxygen Species