Relation between adenosine deaminase activities and cytokine-producing T cells in women with preeclampsia

Clin Biochem. 2002 Jun;35(4):303-6. doi: 10.1016/s0009-9120(02)00318-1.

Abstract

Objectives: To investigate the relation between plasma adenosine deaminase (ADA) activity and cytokine-producing T cells in preeclampsia.

Design and methods: Plasma ADA activity and the proportions of cytokine-producing T cells were measured in peripheral blood of 28 women with normal pregnancies and preeclampsia. The proportion of CD4-positive T cells producing interferon-gamma and interleukin-4 were analyzed by flow cytometry.

Results: Plasma ADA activity in preeclampsia was significantly higher than that in normal pregnancy (p < 0.05). In preeclampsia, the proportion of interferon-gamma producing cells significantly increased, and the proportion of interleukin-4 producing cells was significantly decreased compared with normal pregnancy. A significant correlation was found between ADA activity and the proportion of interferon-gamma producing cells in preeclampsia (r = 0.58, p < 0.05).

Conclusions: Increased plasma ADA activity in preeclampsia may be in part associated with changes in the proportion of interferon-gamma secreting cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Deaminase / blood*
  • Adult
  • Colorimetry / methods
  • Fasting / blood
  • Female
  • Flow Cytometry
  • Humans
  • Interferon-gamma / blood*
  • Interferon-gamma / metabolism
  • Interleukin-4 / blood*
  • Interleukin-4 / metabolism
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / enzymology
  • Pregnancy
  • Statistics as Topic
  • Th1 Cells / cytology
  • Th1 Cells / metabolism*
  • Th2 Cells / cytology
  • Th2 Cells / metabolism*

Substances

  • Interleukin-4
  • Interferon-gamma
  • Adenosine Deaminase