Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant

Nucleic Acids Res. 2002 Aug 1;30(15):3395-400. doi: 10.1093/nar/gkf445.

Abstract

We have identified a putative homologue of the KU70 gene (AtKU70) from Arabidopsis thaliana. In order to study its function in plants we have isolated an A.thaliana line that contains a T-DNA inserted into AtKU70. Plants homozygous for this insertion appear normal and are fertile. In other organisms the KU70 gene has been shown to play a role in the repair of DNA damage induced by ionising radiation (IR) and by radiomimetic chemicals such as methylmethane sulfonate (MMS). We show that AtKU70(-/-) plants are hypersensitive to IR and MMS, and thus the AtKU70 gene plays a similar role in DNA repair in plants as in other organisms. The KU70 gene also plays a role in maintaining telomere length. Yeast and mammalian cells deficient for Ku70 have shortened telomeres. When we studied the telomeres in the AtKU70(-/-) plants we found unexpectedly that they were significantly longer (>30 kb) than was found in wild-type plants (2-4 kb). We propose several hypotheses to explain this telomere lengthening in the AtKU70(-/-) plants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antigens, Nuclear*
  • Arabidopsis / drug effects
  • Arabidopsis / radiation effects
  • Arabidopsis / ultrastructure*
  • Arabidopsis Proteins / genetics*
  • Arabidopsis Proteins / physiology*
  • DNA Damage*
  • DNA Helicases*
  • DNA, Plant / ultrastructure
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology*
  • Genes, Plant
  • Ku Autoantigen
  • Methyl Methanesulfonate / pharmacology
  • Molecular Sequence Data
  • Mutation
  • Nuclear Proteins / genetics
  • Radiation Tolerance
  • Saccharomyces cerevisiae Proteins*
  • Sequence Alignment
  • Telomere / ultrastructure*

Substances

  • Antigens, Nuclear
  • Arabidopsis Proteins
  • DNA, Plant
  • DNA-Binding Proteins
  • KU70 protein, Arabidopsis
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • high affinity DNA-binding factor, S cerevisiae
  • Methyl Methanesulfonate
  • DNA Helicases
  • XRCC5 protein, human
  • Xrcc6 protein, human
  • Ku Autoantigen