RNA interference: the new somatic cell genetics?

Cancer Cell. 2002 Jul;2(1):17-23. doi: 10.1016/s1535-6108(02)00092-2.

Abstract

RNAi is evolving into a powerful tool for manipulating gene expression in mammalian cells with potential utility for investigating gene function, for high-throughput, function-based genetic screens and potentially for development as a therapeutic tool.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Cells, Cultured
  • Cytogenetic Analysis*
  • DNA-Directed RNA Polymerases / metabolism
  • Gene Expression
  • Gene Silencing
  • Humans
  • Models, Genetic
  • RNA, Double-Stranded / chemistry
  • RNA, Double-Stranded / genetics
  • RNA, Small Interfering / chemical synthesis
  • RNA, Small Interfering / genetics*
  • RNA, Small Interfering / metabolism
  • Viral Proteins

Substances

  • RNA, Double-Stranded
  • RNA, Small Interfering
  • Viral Proteins
  • bacteriophage T7 RNA polymerase
  • DNA-Directed RNA Polymerases