Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp

Org Lett. 2002 Aug 22;4(17):2845-8. doi: 10.1021/ol020104+.

Abstract

[structure: see text] Azaspirene isolated from the fungus Neosartorya sp. is a novel angiogenesis inhibitor with a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton. Azaspirene inhibits the endothelial migration induced by vascular endothelial growth factor (ED100 = 27.1 microM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / chemistry*
  • Angiogenesis Inhibitors / isolation & purification
  • Angiogenesis Inhibitors / pharmacology
  • Ascomycota / chemistry
  • Ascomycota / growth & development
  • Ascomycota / isolation & purification
  • Ascomycota / metabolism
  • Cell Movement / drug effects
  • Dose-Response Relationship, Drug
  • Drug Antagonism
  • Endothelial Growth Factors / pharmacology
  • Endothelium, Vascular / cytology
  • Humans
  • Intercellular Signaling Peptides and Proteins / pharmacology
  • Lymphokines / pharmacology
  • Mycotoxins / chemistry*
  • Mycotoxins / isolation & purification
  • Mycotoxins / pharmacology
  • Nuclear Magnetic Resonance, Biomolecular
  • Pyrrolidinones / chemistry*
  • Pyrrolidinones / isolation & purification
  • Pyrrolidinones / pharmacology
  • Soil Microbiology
  • Spiro Compounds / chemistry*
  • Spiro Compounds / isolation & purification
  • Spiro Compounds / pharmacology
  • Umbilical Veins
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • Angiogenesis Inhibitors
  • Endothelial Growth Factors
  • Intercellular Signaling Peptides and Proteins
  • Lymphokines
  • Mycotoxins
  • Pyrrolidinones
  • Spiro Compounds
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • azaspirene