Arrestin and its splice variant Arr1-370A (p44). Mechanism and biological role of their interaction with rhodopsin

J Biol Chem. 2002 Nov 15;277(46):43987-96. doi: 10.1074/jbc.M206211200. Epub 2002 Aug 22.

Abstract

Deactivation of G-protein-coupled receptors relies on a timely blockade by arrestin. However, under dim light conditions, virtually all arrestin is in the rod inner segment, and the splice variant p(44) (Arr(1-370A)) is the stop protein responsible for receptor deactivation. Using size exclusion chromatography and biophysical assays for membrane-bound protein-protein interaction, membrane binding, and G-protein activation, we have investigated the interactions of Arr(1-370A) and proteolytically truncated Arr(3-367) with rhodopsin. We find that these short arrestins do not only interact with the phosphorylated active receptor but also with inactive phosphorylated rhodopsin or opsin in membranes or solution. Because of the latter interaction they are not soluble (like arrestin) but membrane-bound in the dark. Upon photoexcitation, Arr(3-367) and Arr(1-370A) interact with prephosphorylated rhodopsin faster than arrestin and start to quench G(t) activation on a subsecond time scale. The data indicate that in the course of rhodopsin deactivation, Arr(1-370A) is handed over from inactive to active phosphorylated rhodopsin. This mechanism could provide a new aspect of receptor shutoff in the single photon operating range of the rod cell.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing*
  • Animals
  • Arrestin / biosynthesis*
  • Arrestin / genetics*
  • Biophysical Phenomena
  • Biophysics
  • Cattle
  • Centrifugation
  • Chromatography
  • Dose-Response Relationship, Drug
  • Kinetics
  • Light
  • Models, Biological
  • Models, Chemical
  • Models, Molecular
  • Protein Binding
  • Retinal Rod Photoreceptor Cells / metabolism
  • Rhodopsin / metabolism*
  • Rhodopsin / physiology
  • Scattering, Radiation
  • Thermodynamics

Substances

  • Arrestin
  • Rhodopsin