Abstract
In this study, 12 new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridindione derivatives were synthesised and their effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rabbit thoracic arteries was investigated. Pinacidil was used as standard potassium channel openers in this study. Compounds 1-12 and pinacidil exerted concentration-dependent relaxation responses precontracted phenylephrine in the aortic rings with the efficacy order: 11>pinacidil>7>2>8>3>1>4>10>6>9>5>12.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines / chemical synthesis*
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Acridines / pharmacology*
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Animals
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Aorta, Thoracic / drug effects
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Glyburide / pharmacology
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Hypoglycemic Agents / pharmacology
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In Vitro Techniques
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Kinetics
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Magnetic Resonance Spectroscopy
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Male
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Molecular Weight
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Muscle, Smooth, Vascular / drug effects*
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Phenylephrine / antagonists & inhibitors
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Pinacidil / pharmacology
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Potassium Channels / agonists*
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Rabbits
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Tetraethylammonium Compounds / pharmacology
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Vasoconstrictor Agents / antagonists & inhibitors
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Vasodilator Agents / chemical synthesis*
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Vasodilator Agents / pharmacology*
Substances
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Acridines
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Hypoglycemic Agents
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Potassium Channels
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Tetraethylammonium Compounds
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Vasoconstrictor Agents
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Vasodilator Agents
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Phenylephrine
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Pinacidil
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Glyburide