Abstract
Intracytoplasmic inclusions composed of alpha-synuclein (alpha-syn) are characteristic of neurodegenerative Lewy body disorders. Using novel monoclonal antibodies raised against altered alpha-syn, we uncovered an unprecedented and extensive burden of alpha-syn pathology in the striatum of Lewy body disorders. The highest density of striatal pathology was observed in patients with a combination of Alzheimer's disease and dementia with Lewy bodies or pure dementia with Lewy bodies, and these alpha-syn aggregates may contribute to the parkinsonism seen in these disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Monoclonal
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Corpus Striatum / metabolism*
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Corpus Striatum / pathology*
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Humans
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Lewy Body Disease / metabolism*
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Lewy Body Disease / pathology*
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Molecular Weight
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / immunology
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Nerve Tissue Proteins / metabolism*
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Nitrates / metabolism
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Peptide Fragments / metabolism
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Synucleins
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alpha-Synuclein
Substances
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Antibodies, Monoclonal
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Nerve Tissue Proteins
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Nitrates
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Peptide Fragments
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SNCA protein, human
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Synucleins
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alpha-Synuclein