Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2855-8. doi: 10.1016/s0960-894x(02)00632-7.

Abstract

A 1X22X41 combinatorial library or 902 compounds of indinavir analogues was synthesized on the solid support to identify a replacement for the aminoindanol moiety at P2'. 2,6-Dimethyl-4-hydroxy phenol was discovered to be a good replacement for aminoindanol.

MeSH terms

  • Combinatorial Chemistry Techniques
  • HIV Protease / chemistry
  • HIV Protease / drug effects
  • HIV Protease Inhibitors / chemical synthesis*
  • HIV Protease Inhibitors / pharmacokinetics
  • HIV Protease Inhibitors / pharmacology*
  • Humans
  • Indicators and Reagents
  • Indinavir / analogs & derivatives*
  • Indinavir / chemical synthesis*
  • Indinavir / pharmacokinetics
  • Models, Molecular
  • Structure-Activity Relationship

Substances

  • HIV Protease Inhibitors
  • Indicators and Reagents
  • Indinavir
  • HIV Protease