Abstract
A 1X22X41 combinatorial library or 902 compounds of indinavir analogues was synthesized on the solid support to identify a replacement for the aminoindanol moiety at P2'. 2,6-Dimethyl-4-hydroxy phenol was discovered to be a good replacement for aminoindanol.
MeSH terms
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Combinatorial Chemistry Techniques
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HIV Protease / chemistry
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HIV Protease / drug effects
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HIV Protease Inhibitors / chemical synthesis*
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HIV Protease Inhibitors / pharmacokinetics
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HIV Protease Inhibitors / pharmacology*
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Humans
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Indicators and Reagents
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Indinavir / analogs & derivatives*
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Indinavir / chemical synthesis*
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Indinavir / pharmacokinetics
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Models, Molecular
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Structure-Activity Relationship
Substances
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HIV Protease Inhibitors
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Indicators and Reagents
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Indinavir
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HIV Protease