Neurocognitive dimensions characterising patients with first-episode psychosis

Br J Psychiatry Suppl. 2002 Sep:43:s85-90. doi: 10.1192/bjp.181.43.s85.

Abstract

Background: Assessment of neurocognitive dysfunction in schizophrenia is hampered by the multitude of tests used in the literature.

Aims: We aimed to identify the main dimensions of an assessment battery for patients with first-episode psychosis and to estimate the relationship between dimension scores and gender, age, education, diagnosis and symptoms.

Method: Eight frequently used neuropsychological tests were used. We tested 219 patients 3 months after start of therapy or at remission, whichever occurred first.

Results: We identified five dimensions: working memory (WM); verbal learning (VL); executive function (EF); impulsivity (im); and motor speed (MS). Significant findings were that the MS score was higher for men, and the WM and VL scores were correlated with years of education.

Conclusions: Neurocognitive function in first-episode psychosis is described by at least five independent dimensions.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Cognition
  • Education
  • Female
  • Humans
  • Impulsive Behavior / psychology
  • Male
  • Memory
  • Neuropsychological Tests
  • Psychomotor Performance
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / psychology*
  • Schizophrenia / diagnosis
  • Schizophrenic Psychology*
  • Sex Factors
  • Verbal Learning