Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852)

J Nat Prod. 2002 Sep;65(9):1344-5. doi: 10.1021/np010577+.

Abstract

A new antiangiogenic compound, bryoanthrathiophene (1), together with two known compounds, 5,7-dihydroxy-1-methoxycarbonyl-6-oxo-6H-anthra[1,9-bc]thiophene (2) and 1,8-dihydroxyanthraquinone (3), was isolated from the bryozoan Watersipora subtorquata (d'Orbigny, 1852) using bioassay-guided fractionation methods. Among them, bryoanthrathiophene (1) exhibited the most potent antiangiogenic activity on BAEC (bovine aorta endothelial cell) proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / chemistry
  • Angiogenesis Inhibitors / isolation & purification*
  • Angiogenesis Inhibitors / pharmacology
  • Animals
  • Anthraquinones / chemistry
  • Anthraquinones / isolation & purification*
  • Anthraquinones / pharmacology
  • Aorta / cytology*
  • Aorta / drug effects*
  • Bryozoa / chemistry*
  • Cattle
  • Cells, Cultured / drug effects
  • Endothelium, Vascular / drug effects*
  • Japan
  • Lymphokines
  • Thiophenes / chemistry
  • Thiophenes / isolation & purification*
  • Thiophenes / pharmacology

Substances

  • 5,7-dihydroxy-1-methoxycarbonyl-6-oxo-6H-anthra(1,9-bc)thiophene
  • Angiogenesis Inhibitors
  • Anthraquinones
  • Lymphokines
  • Thiophenes
  • bryoanthrathiophene
  • danthron