Dose escalation, safety and immunogenicity study of a tetravalent meninogococcal polysaccharide diphtheria conjugate vaccine in toddlers

Pediatr Infect Dis J. 2002 Oct;21(10):978-9. doi: 10.1097/00006454-200210000-00019.

Abstract

Two injections of tetravalent (Groups A, C, Y and W-135) meningococcal polysaccharide vaccine conjugated to diphtheria were given to 30 toddlers at dosages of 1, 4 and 10 microg/ml polysaccharide of each serogroup. Reactogenicity was acceptable at all dosages. The 4-microg/ml dose appears to be immunologically optimal.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Antigens, Bacterial / analysis*
  • Child, Preschool
  • Dose-Response Relationship, Drug
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunity / physiology*
  • Immunization Schedule
  • Infant
  • Male
  • Meningococcal Infections / prevention & control*
  • Meningococcal Vaccines / administration & dosage*
  • Polysaccharides, Bacterial
  • Safety
  • Sensitivity and Specificity
  • Treatment Outcome
  • Vaccination / methods*
  • Vaccines, Conjugate

Substances

  • Antigens, Bacterial
  • Meningococcal Vaccines
  • Polysaccharides, Bacterial
  • Vaccines, Conjugate