Obliteration of femoral artery pseudoaneurysm by thrombin injection

Ann Thorac Surg. 2002 Oct;74(4):S1413-5. doi: 10.1016/s0003-4975(02)03969-3.

Abstract

Background: Femoral artery pseudyoaneurysms are a common complication after femoral access for transcatheter procedures, frequently requiring operative repair. We review the safety and efficacy of a novel nonsurgical method of pseudoaneurysm treatment

Methods: From June 1998 to November 2001, a total of 47 femoral artery pseudoaneurysms in 46 patients were treated by bedside ultrasound-guided injection of dilute topical thrombin. All pseudoaneurysms occurred after femoral access for transcatheter procedures, and were diagnosed clinically and confirmed with ultrasound imaging. Clinical follow-up was performed and included ultrasound (2 hours to 1 month) in 64.4% of patients, including any patient with a symptomatic or clinical change.

Results: Pseudoaneurysms ranged in size from 1.5 to 4.5 cm. Of 47 pseudoaneurysms, 45 were successfully obliterated on the initial injection. After successful obliteration of pseudoaneurysm, 1 patient sustained thrombosis of the tibioperoneal trunk that required surgical embolectomy, yielding a complication rate of 2%. Four pseudoaneurysms recurred after initially successful obliteration. In 1 of these cases, the patient was taken directly to surgery, and 3 were successfully treated with repeat injection, for an overall success rate of 93.6%.

Conclusions: Obliteration of femoral artery pseudoaneurysm by injection is safe and effective, and may be associated with decreased morbidity. Recurrent pseudoaneurysms may be safely reinjected, with a high success rate.

MeSH terms

  • Aneurysm, False / diagnostic imaging
  • Aneurysm, False / drug therapy*
  • Catheterization / adverse effects*
  • Femoral Artery*
  • Humans
  • Injections
  • Recurrence
  • Thrombin / administration & dosage*
  • Treatment Outcome
  • Ultrasonography

Substances

  • Thrombin