[Identification of a novel substrate of Alzheimer's beta-secretase: beta-secretase dependent cleavage of alpha 2,6 sialyltransferase]

Seikagaku. 2002 Sep;74(9):1180-3.

[Article in Japanese]

Authors

Shinobu Kitazume¹, Takaomi C Saido, Yasuhiro Hashimoto

Affiliation

¹ Glyco-chain Functions Laboratory, Frontier Research System, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198.

PMID: 12402461

No abstract available

Publication types

Review

MeSH terms

Alzheimer Disease / drug therapy
Alzheimer Disease / etiology*
Alzheimer Disease / metabolism
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor / metabolism
Animals
Aspartic Acid Endopeptidases / antagonists & inhibitors
Aspartic Acid Endopeptidases / physiology*
Endopeptidases
Humans
Sialyltransferases / metabolism*
beta-D-Galactoside alpha 2-6-Sialyltransferase

Substances

Amyloid beta-Protein Precursor
Sialyltransferases
Amyloid Precursor Protein Secretases
Endopeptidases
Aspartic Acid Endopeptidases
BACE1 protein, human
beta-D-Galactoside alpha 2-6-Sialyltransferase