Quinacrine-induced psychiatric disturbances in a child with common variable immunodeficiency and chronic giardiasis

Hum Psychopharmacol. 2002 Oct;17(7):357-9. doi: 10.1002/hup.427.

Abstract

Psychiatric disorders due to quinacrine for antiparasitic therapy represent an infrequent, but serious, complication. The remarkable course of a 12-year-old boy with common variable immunodeficiency who developed severe psychiatric reactions following quinacrine therapy for his resistant chronic giardiasis is presented. The broad clinical spectrum of quinacrine-associated neuropsychiatric disturbances has been emphasized for the clinicians.

Publication types

  • Case Reports

MeSH terms

  • Anti-Anxiety Agents / therapeutic use
  • Antiprotozoal Agents / adverse effects*
  • Antiprotozoal Agents / therapeutic use
  • Antipsychotic Agents / therapeutic use
  • Benzodiazepines
  • Child
  • Chronic Disease
  • Common Variable Immunodeficiency / complications*
  • Common Variable Immunodeficiency / parasitology
  • Common Variable Immunodeficiency / psychology
  • Drug Resistance
  • Giardiasis / complications*
  • Giardiasis / parasitology
  • Giardiasis / psychology
  • Haloperidol / therapeutic use
  • Humans
  • Male
  • Psychoses, Substance-Induced / psychology*
  • Quinacrine / adverse effects*
  • Quinacrine / therapeutic use

Substances

  • Anti-Anxiety Agents
  • Antiprotozoal Agents
  • Antipsychotic Agents
  • Benzodiazepines
  • Quinacrine
  • Haloperidol