Subacute leukencephalopathy after low-dose intrathecal methotrexate in an adolescent heterozygous for the MTHFR C677T polymorphism

Med Pediatr Oncol. 2003 Jan;40(1):48-50. doi: 10.1002/mpo.10192.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antimetabolites, Antineoplastic / administration & dosage*
  • Antimetabolites, Antineoplastic / adverse effects*
  • Heterozygote
  • Humans
  • Injections, Spinal
  • Leukoencephalitis, Acute Hemorrhagic / chemically induced*
  • Male
  • Methotrexate / administration & dosage*
  • Methotrexate / adverse effects*
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Oxidoreductases Acting on CH-NH Group Donors / genetics*
  • Polymorphism, Genetic*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

Substances

  • Antimetabolites, Antineoplastic
  • Oxidoreductases Acting on CH-NH Group Donors
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Methotrexate