Superoxide dismutase activity and electrochemical study of the binuclear [Cu(TSA)2py]2 complex

J Trace Elem Med Biol. 2002;16(3):183-6. doi: 10.1016/s0946-672x(02)80023-2.

Abstract

The superoxide dismutase-mimetic activity and the electrochemical behavior of the binuclear complex [Cu(TSA)2py]2 is reported. The complex exhibits a marked SOD activity in the nitroblue tetrazolium assay. Its redox response is in agrement with two copper atoms partially coupled through the carboxylate moieties. The electrode reactions lie in the range of the superoxide/peroxide and oxygen/superoxide couples. This fact is indicative that this complex can act as catalyst for the SOD reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalysis
  • Cattle
  • Copper / chemistry*
  • Copper / pharmacology
  • Electrochemistry
  • Erythrocytes / enzymology
  • Indicators and Reagents / pharmacology
  • Models, Chemical
  • Nitroblue Tetrazolium / pharmacology
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / pharmacology
  • Oxidation-Reduction
  • Oxygen / metabolism
  • Salicylates / metabolism
  • Sulfhydryl Compounds
  • Superoxide Dismutase / metabolism*
  • Thermodynamics

Substances

  • Indicators and Reagents
  • Organometallic Compounds
  • Salicylates
  • Sulfhydryl Compounds
  • Nitroblue Tetrazolium
  • Copper
  • thiosalicylic acid
  • Superoxide Dismutase
  • Oxygen