Abstract
Although the adult brain contains nicotinic acetylcholine (ACh) receptors vital to cortical function, little is known about the assembly of embryonic receptor subunits into functional receptors or their role in fetal brain development. We now report the first evidence of functional nicotinic ACh receptors on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / embryology*
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Calcium / metabolism
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Cell Differentiation
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Cerebral Cortex / embryology*
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Electrophysiology
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Mice
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Receptors, Nicotinic / biosynthesis*
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Stem Cells / metabolism*
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Time Factors
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alpha7 Nicotinic Acetylcholine Receptor
Substances
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Chrna7 protein, mouse
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Receptors, Nicotinic
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alpha7 Nicotinic Acetylcholine Receptor
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nicotinic acetylcholine receptor alpha4 subunit
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nicotinic receptor subunit alpha3
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Calcium