Intrathecal morphine overdose during combined spinal-epidural block for Caesarean delivery

Br J Anaesth. 2002 Dec;89(6):925-7. doi: 10.1093/bja/aef286.

Abstract

We describe a 25 mg intrathecal morphine overdose during a combined spinal-epidural block for a Caesarean delivery. Naloxone infusion (5.24 mg over 24 h) was started prior to the patient becoming symptomatic and almost immediately after the overdose. Invasive therapeutics such as mechanical ventilation were avoided.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / adverse effects*
  • Analgesics, Opioid / blood
  • Anesthesia, Epidural / methods
  • Anesthesia, Obstetrical / methods*
  • Anesthesia, Spinal / methods
  • Cesarean Section*
  • Drug Overdose / therapy
  • Female
  • Humans
  • Injections, Spinal
  • Medication Errors* / adverse effects
  • Morphine / administration & dosage
  • Morphine / adverse effects*
  • Morphine / blood
  • Pregnancy

Substances

  • Analgesics, Opioid
  • Morphine