Abstract
CBS1 from Magnaporthe grisea is a structural and functional homolog of the cystathionine beta-synthase (CBS) gene from Saccharomyces cerevisiae. Our studies indicated that M. grisea can utilize homocysteine and methionine through a CBS-independent pathway. The results also revealed responses of M. grisea to homocysteine that are reminiscent of human homocystinuria.
MeSH terms
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Amino Acid Sequence
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Cystathionine / chemistry
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Cystathionine beta-Synthase / chemistry
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Cystathionine beta-Synthase / genetics*
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Genes, Fungal*
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Homocysteine / pharmacology
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Magnaporthe / genetics*
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Magnaporthe / growth & development
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Mitochondrial Proteins / genetics
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Molecular Sequence Data
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Plant Diseases / genetics
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Saccharomyces cerevisiae Proteins / genetics
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Sequence Alignment
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Sequence Analysis, Protein
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Trans-Activators / genetics
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Vitamin B 12 / metabolism
Substances
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CBS1 protein, S cerevisiae
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Mitochondrial Proteins
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Saccharomyces cerevisiae Proteins
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Trans-Activators
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Homocysteine
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Cystathionine
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Cystathionine beta-Synthase
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Vitamin B 12