The core structure of TMC-95A is a promising lead for reversible proteasome inhibition

Angew Chem Int Ed Engl. 2002 Mar 1;41(5):780-3. doi: 10.1002/1521-3773(20020301)41:5<780::aid-anie780>3.0.co;2-v.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cysteine Endopeptidases
  • Endopeptidases
  • Inhibitory Concentration 50
  • Molecular Conformation
  • Multienzyme Complexes / antagonists & inhibitors*
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / pharmacology
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology
  • Proteasome Endopeptidase Complex
  • Yeasts / enzymology

Substances

  • Multienzyme Complexes
  • Peptides, Cyclic
  • Protease Inhibitors
  • TMC-95A
  • Endopeptidases
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex