Chronic metoclopramide therapy for diabetic gastroparesis

Ann Pharmacother. 2003 Jan;37(1):122-6. doi: 10.1345/aph.1C118.

Abstract

Objective: To review the safety and efficacy of chronic metoclopramide for diabetic gastroparesis.

Data sources: Medical literature was accessed through MEDLINE (1965 to October 2002) and PubMed (1965 to October 2002). Key search terms included metoclopramide; diabetic gastroparesis; and dyskinesia, drug induced.

Data synthesis: Metoclopramide is often used for diabetic gastroparesis, despite the risk of tardive dyskinesia. Published information is limited regarding long-term efficacy and toxicity of metoclopramide. The literature was assessed concerning these topics.

Conclusions: Limited data do not provide sufficient evidence to conclude whether metoclopramide is efficacious for chronic use. Routine monitoring may mitigate the risk associated with metoclopramide therapy.

Publication types

  • Review

MeSH terms

  • Antiemetics / administration & dosage*
  • Antiemetics / adverse effects
  • Antiemetics / therapeutic use*
  • Diabetes Complications*
  • Drug Administration Schedule
  • Gastroparesis / drug therapy*
  • Gastroparesis / etiology
  • Humans
  • Metoclopramide / administration & dosage*
  • Metoclopramide / adverse effects
  • Metoclopramide / therapeutic use*
  • Randomized Controlled Trials as Topic

Substances

  • Antiemetics
  • Metoclopramide