Ecological risk assessment of persistent organic chemicals in marine mammals in the Arctic would comprise assessments of both exposure and effect and risk characterization. Results from a comprehensive collaborative study between Norwegian and Canadian researchers, comprising epizoological (ecological) studies (reproductive rate, offspring survival), experimental studies on the immune system function, monitoring studies (e.g. physiological assays of thyroid hormones, retinol, IgG and testosterone) and registration of biological data (e.g. sex, age, reproductive status, nutritional status) were coupled with PCB exposure data. Assessment of the results indicates that population status and health of polar bears with very high PCB levels may be at risk.