The quest for a vascular endothelial cannabinoid receptor

Chem Phys Lipids. 2002 Dec 31;121(1-2):45-56. doi: 10.1016/s0009-3084(02)00145-7.

Abstract

This review examines pharmacological and biochemical evidence that suggests the existence of an as yet undefined endothelial receptor that mediates endocannabinoid-induced vasodilation. The signaling mechanisms triggered through this receptor and its potential physiological role are also discussed. Since vasodilation is often associated with hypotension, mechanisms involved in the hypotensive actions of cannabinoids, including the endocannabinoids anandamide and 2-arachidonoylglycerol, are also briefly reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Arachidonic Acids / pharmacology
  • Cannabinoid Receptor Modulators
  • Cannabinoids / metabolism
  • Cannabinoids / pharmacology*
  • Endocannabinoids
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / physiology*
  • GTP-Binding Proteins / metabolism
  • Glycerides / pharmacology
  • Humans
  • Polyunsaturated Alkamides
  • Receptors, Cannabinoid
  • Receptors, Drug / metabolism
  • Receptors, Drug / physiology*
  • Vasodilation / drug effects
  • Vasodilation / physiology

Substances

  • Arachidonic Acids
  • Cannabinoid Receptor Modulators
  • Cannabinoids
  • Endocannabinoids
  • Glycerides
  • Polyunsaturated Alkamides
  • Receptors, Cannabinoid
  • Receptors, Drug
  • glyceryl 2-arachidonate
  • GTP-Binding Proteins
  • anandamide