[Fatty acid synthase: specific target for cancer therapy]

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Jan;35(1):1-5.
[Article in Chinese]

Abstract

Fatty acids, the products of fatty acid synthesis, are essential components and forms of energy for cancer growth. Compared to normal human tissues, many common human cancers express elevated levels of fatty acid synthase (FAS), the important enzyme responsible for the synthesis of fatty acid, suggesting FAS can be a specific target for cancer therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Catechin / analogs & derivatives*
  • Catechin / pharmacology
  • Cerulenin / pharmacology
  • Fatty Acid Synthases / antagonists & inhibitors*
  • Fatty Acid Synthases / metabolism
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology
  • Triclosan / pharmacology

Substances

  • Cerulenin
  • Triclosan
  • Catechin
  • Fatty Acid Synthases
  • gallocatechol