Deoligomerization: a new route to lactams from unsaturated amides via radical oligomerization

Org Lett. 2003 Feb 6;5(3):361-3. doi: 10.1021/ol027428i.

Abstract

[reaction: see text] Triethylborane-initiated atom transfer radical oligomerization of N-allyl or N-(3-butenyl)iodoacetamides followed by treatment with hydrochloric acid and subsequent neutralization with K(2)CO(3) led to the formation of the corresponding 5-hydroxyl-substituted delta-lactams or caprolactams, respectively. This oligomerization-deoligomerization sequence serves as an alternative to the corresponding intramolecular cyclization reactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Caprolactam / analogs & derivatives
  • Caprolactam / chemical synthesis
  • Caprolactam / chemistry
  • Cyclization
  • Lactams / chemical synthesis*
  • Lactams / chemistry
  • Molecular Structure

Substances

  • Amides
  • Lactams
  • Caprolactam