To explore the relationship of parent-child communication to youth drug involvement, we analyzed secondary data from substance-abuse surveys given to 82,918 7th-12th graders in the U.S. It was found that: (a) parents are most often identified as the individuals who have talked to a child about drugs; (b) youth consider parents to be credible sources of information about drugs; (c) as perceived family sanctions go up, drug involvement goes down; (d) youth with the highest levels of drug involvement are the group most likely both to have had no one talk to them and to have had the largest number of people talk to them about drugs; and (e) perceived family sanctions increase dramatically for highly drug-involved youth once they have been talked to by one person.