Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL

Rodrig Marculescu; Katrina Vanura; Trang Le; Paul Simon; Ulrich Jäger; Bertrand Nadel

doi:10.1038/ng1092

Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL

Nat Genet. 2003 Mar;33(3):342-4. doi: 10.1038/ng1092. Epub 2003 Feb 3.

Authors

Rodrig Marculescu¹, Katrina Vanura, Trang Le, Paul Simon, Ulrich Jäger, Bertrand Nadel

Affiliation

¹ Department of Internal Medicine I, Division of Hematology, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

PMID: 12567187
DOI: 10.1038/ng1092

Abstract

After V(D)J-mediated translocations, signal joints are retained on one of the derivative chromosomes. We report here that such signal joints are highly reactive and constitute unstable genomic elements with potential oncogenic properties.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Chromosome Breakage
Chromosomes, Human, Pair 7 / genetics*
Chromosomes, Human, Pair 9 / genetics*
DNA / genetics
DNA-Binding Proteins / genetics
Gene Expression Regulation
Humans
Leukemia-Lymphoma, Adult T-Cell / genetics*
Models, Genetic
Molecular Sequence Data
Neoplasm Proteins / genetics
Sequence Homology, Nucleic Acid
Translocation, Genetic*

Substances

Basic Helix-Loop-Helix Transcription Factors
DNA-Binding Proteins
Neoplasm Proteins
TAL2 protein, human
DNA