Purpose: To study the expression of P21waf1/cip1 protein in eye-lip primary malignant tumor (E-LPMT).
Methods: Immunohistochemical streptavidin biotin peroxidase complex(SP) method was used to stain section of E-LPMT.
Results: In 61 cases of E-LPMT, positive expression of P21waf1/cip1 protein was found locating in the nuclei. In Cell carcinoma, Squamous and Adenocarcinomas, the positive rate of P21waf1/cip1 protein expression were 36.0%, 27.8% and 22.2% respectively. The positive rate of P21waf1/cip1 protein expression in well-differentiated Cell carcinomas or Adenocarcinomas was higher than in poor-differentiated ones (P < 0.01).
Conclusion: P21waf1/cip1 protein expresses in various type of E-IPMT and its positive expression in Cell carainomas and Adenocarcinomas are related to their different degrees.