[The Feature of Skewing Distribution of TCR Vbeta T Cells from Peripheral Blood and Bone Marrow in Patients with AML-M(5)]

Lijian Yang; Yangqiu Li; Shaohua Chen; Mingfang Qi; Yuhong Lu; Gengxin Luo

[The Feature of Skewing Distribution of TCR Vbeta T Cells from Peripheral Blood and Bone Marrow in Patients with AML-M(5)]

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2000 Sep;8(3):196-198.

[Article in Chinese]

Authors

Lijian Yang¹, Yangqiu Li, Shaohua Chen, Mingfang Qi, Yuhong Lu, Gengxin Luo

Affiliation

¹ Department of Hematology, Medical College, Jinan University, Guangzhou 510632, China; Deptartment of Hematology, The First Affiliated Hospitol of Medical College, Jinan University, Guangzhou 510632, China.

PMID: 12578682

Abstract

The TCR Vbeta 24 subfamily genes were amplified in peripheral blood and bone marrow mononuclear cells from 5 cases with acute monocytic leukemia (AML-M(5)) using RT-PCR, to observe the distribution of TCR Vbeta subfamilies. The results indicated that 1 - 19 Vbeta subfamily T cells could be identified in different samples from AML-M(5) cases. The variation of distribution of TCR Vbeta subfamily T cells could be found in different individual samples. The results provided the feature of cell immune function change in skewed distribution of TCR Vbeta subfamily T cells from peripheral blood and bone marrow of patients with AML-M(5).