Effects of HIV triple therapy on methadone levels

Am J Addict. 2002 Fall;11(4):308-14. doi: 10.1080/1055049029008810.

Abstract

There is a belief among methadone patients that triple therapy for HIV reduces methadone potency. This cross-sectional study compared the rate of methadone metabolism (peak-trough blood levels) in two groups of methadone-maintained patients, AIDS patients receiving triple therapy (N = 17), and HIV patients without triple therapy (N = 19). These preliminary findings suggest that triple therapy may increase the rate of methadone metabolism, though further studies are warranted.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / drug therapy
  • Adolescent
  • Adult
  • Aged
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / therapeutic use*
  • Cross-Sectional Studies
  • Drug Interactions
  • Drug Therapy, Combination
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • Heroin Dependence / complications
  • Heroin Dependence / rehabilitation*
  • Humans
  • Male
  • Methadone / blood*
  • Methadone / pharmacokinetics
  • Methadone / therapeutic use*
  • Middle Aged

Substances

  • Anti-HIV Agents
  • Methadone