Relapse of coccidioidomycosis despite immune reconstitution after fluconazole secondary prophylaxis in a patient with AIDS

G Mathew; M Smedema; L J Wheat; M Goldman

doi:10.1046/j.1439-0507.2003.00833.x

Relapse of coccidioidomycosis despite immune reconstitution after fluconazole secondary prophylaxis in a patient with AIDS

Mycoses. 2003 Feb;46(1-2):42-4. doi: 10.1046/j.1439-0507.2003.00833.x.

Authors

G Mathew¹, M Smedema, L J Wheat, M Goldman

Affiliation

¹ Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

PMID: 12588482
DOI: 10.1046/j.1439-0507.2003.00833.x

Abstract

We report a case of relapse of coccidioidomycosis in an HIV-infected person who discontinued maintenance azole therapy following a response to antiretroviral therapy. This experience raises concern about the safety of withholding secondary prophylaxis for coccidioidomycosis in persons with HIV infection who have achieved immunological responses to antiretroviral therapy.

Publication types

Case Reports
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

AIDS-Related Opportunistic Infections / drug therapy
AIDS-Related Opportunistic Infections / immunology
AIDS-Related Opportunistic Infections / prevention & control*
Antifungal Agents / therapeutic use*
Coccidioidomycosis / drug therapy
Coccidioidomycosis / prevention & control*
Drug Therapy, Combination
Fluconazole / therapeutic use*
HIV Infections / complications
HIV Infections / immunology*
HIV Infections / microbiology
Humans
Male
Middle Aged
Recurrence
Withholding Treatment

Substances

Antifungal Agents
Fluconazole