Paecilomyces variotii central nervous system infection in a patient with cancer

Mycoses. 2003 Feb;46(1-2):45-50. doi: 10.1046/j.1439-0507.2003.00837.x.

Abstract

Paecilomyces variotii was isolated from two subsequent cerebrospinal fluid (CSF) specimens of a cancer patient. Identification was confirmed through beta-tubulin and rDNA ITS sequencing. MICs were determined for seven antifungal agents; the isolate was found to be susceptible to amphotericin B (AMB), itraconazole (ITZ), ketaconazole (KTZ) and 5-fluorocytosine (5FC) but resistant to fluconazole (FLZ) and miconazole (MCZ). Despite antimycotic therapy, the infection proved to be fatal.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use
  • Breast Neoplasms / complications*
  • Central Nervous System Infections / drug therapy
  • Central Nervous System Infections / etiology*
  • Cerebrospinal Fluid / microbiology
  • Female
  • Humans
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycoses / drug therapy
  • Mycoses / etiology*
  • Opportunistic Infections
  • Paecilomyces / drug effects
  • Paecilomyces / genetics
  • Paecilomyces / isolation & purification*
  • Triazoles / pharmacology
  • Triazoles / therapeutic use

Substances

  • Antifungal Agents
  • Triazoles