Localization of angiotensin II (AT1)-receptor-immunoreactive fibres in the hypothalamus of rats: angiotensin II-sensitive tanycytes in the ependyma of the third ventricle?

Brain Res. 2003 Mar 28;967(1-2):281-4. doi: 10.1016/s0006-8993(02)04242-7.

Abstract

Scanning the hypothalamus of rats for receptor binding sites of the octapeptide hormone angiotensin II (ANG II), we observed ANG II-sensitive fibres in the ventrolateral hypothalamus. The ANG II (AT(1))-receptor-immunoreactive processes originate from cells-probably tanycytes-embedded in the base and the ventrolateral walls of the third ventricle and reach into the retrochiasmatic area, the ventrolateral hypothalamus and the median eminence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / analysis
  • Animals
  • Ependyma / chemistry*
  • Hypothalamus / chemistry*
  • Immunochemistry
  • Male
  • Nerve Fibers / chemistry*
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Angiotensin, Type 1
  • Receptors, Angiotensin / analysis*
  • Third Ventricle / chemistry*

Substances

  • Receptor, Angiotensin, Type 1
  • Receptors, Angiotensin
  • Angiotensin II