Trisomy X in Philadelphia chromosome-negative cells during the course of Philadelphia chromosome-positive chronic myelocytic leukemia

Cancer Genet Cytogenet. 2003 Apr 1;142(1):83-5. doi: 10.1016/s0165-4608(02)00800-2.

Abstract

A Philadelphia chromosome-negative (Ph(-)) clone with trisomy X appeared in the bone marrow cells from a patient with Ph(+) chronic myelocytic leukemia in the chronic phase after hydroxyurea and interferon-alpha treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use
  • Chromosomes, Human, X*
  • Clone Cells / pathology
  • Disease Progression
  • Female
  • Humans
  • Hydroxyurea / adverse effects
  • Hydroxyurea / therapeutic use
  • Interferon-alpha / adverse effects
  • Interferon-alpha / therapeutic use
  • Karyotyping
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology
  • Trisomy*

Substances

  • Antineoplastic Agents
  • Interferon-alpha
  • Hydroxyurea