MR imaging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients

Eur Radiol. 2003 May;13(5):986-93. doi: 10.1007/s00330-002-1594-9. Epub 2002 Sep 10.

Abstract

Our objective was to investigate brain MR imaging findings and the utility of diffusion-weighted (DW) imaging in organ transplant patients who developed neurologic symptoms during tacrolimus therapy. Brain MR studies, including DW imaging, were prospectively performed in 14 organ transplant patients receiving tacrolimus who developed neurologic complications. In each patient who had abnormalities on the initial MR study, a follow-up MR study was performed 1 month later. Apparent diffusion coefficient (ADC) values on the initial MR study were correlated with reversibility of the lesions. Of the 14 patients, 5 (35.7%) had white matter abnormalities, 1 (7.1%) had putaminal hemorrhage, and 8 (57.1%) had normal findings on initial MR images. Among the 5 patients with white matter abnormalities, 4 patients (80.0%) showed higher than normal ADC values on initial MR images, and all showed complete resolution on follow-up images. The remaining 1 patient (20.0%) showed lower than normal ADC value and showed incomplete resolution with cortical laminar necrosis. Diffusion-weighted imaging may be useful in predicting the outcomes of the lesions of tacrolimus-induced neurotoxicity.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adult
  • Brain / drug effects*
  • Brain / physiology*
  • Brain Mapping*
  • Child
  • Child, Preschool
  • Diffusion Magnetic Resonance Imaging*
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / blood
  • Immunosuppressive Agents / toxicity*
  • Infant
  • Japan
  • Male
  • Middle Aged
  • Neurotoxicity Syndromes / blood
  • Neurotoxicity Syndromes / etiology*
  • Neurotoxicity Syndromes / physiopathology
  • Organ Transplantation*
  • Postoperative Complications / blood
  • Postoperative Complications / etiology
  • Prospective Studies
  • Severity of Illness Index
  • Tacrolimus / administration & dosage
  • Tacrolimus / blood
  • Tacrolimus / toxicity*
  • Treatment Failure

Substances

  • Immunosuppressive Agents
  • Tacrolimus